Python UV Package Management Best Practices: Exclusive Dependency Handling Guide

1. **Adopt UV as Your Sole Dependency Manager**: Enforce UV for all installations, synchronizations, and lockfile generations in Python projects. Prohibit alternatives like pip, pip-tools, or poetry to ensure consistency and speed.

2. **Master Core Dependency Commands**: Use `uv add <package>` to install or update packages, `uv remove <package>` to eliminate them, and `uv sync` to reinstall everything from the lockfile, keeping your environment precise and reproducible.

3. **Execute Scripts with Dependency Awareness**: Launch Python scripts via `uv run script.py` to automatically resolve and load required dependencies without manual activation.

4. **Embed Dependencies Directly in Scripts**: Customize script metadata inline using comments like `/// script` blocks to specify Python version and packages (e.g., requires-python and dependencies list), enabling self-contained execution.

5. **Handle Script-Specific Dependencies via CLI**: Target individual scripts with `uv add package-name --script script.py` for additions/updates, `uv remove package-name --script script.py` for removals, and `uv sync --script script.py` for lockfile-based reinstalls.