Preprint
Machine Learning

Accuracy Analysis of Deep Learning Methods in Breast Cancer Classification: A Structured Review

Marina Yusoff(Institute for Big Data Analytics and Artificial Intelligence (IBDAAI), Kompleks Al-Khawarizmi, Universiti Teknologi MARA (UiTM), Shah Alam 40450, Selangor, Malaysia), Toto Haryanto(Department of Computer Science, IPB University, Bogor 16680, Indonesia), Heru Suhartanto(Faculty of Computer Science, Universitas Indonesia, Depok 16424, Indonesia), Wan Azani Mustafa(Faculty of Electrical Engineering Technology, Universiti Malaysia Perlis, UniCITI Alam Campus, Sungai Chuchuh, Padang Besar 02100, Perlis, Malaysia), Jasni Mohamad Zain(Institute for Big Data Analytics and Artificial Intelligence (IBDAAI), Kompleks Al-Khawarizmi, Universiti Teknologi MARA (UiTM), Shah Alam 40450, Selangor, Malaysia), Kusmardi Kusmardi(Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia)
February 11, 2023Diagnostics37 citations

37

Citations

0

Influential Citations

Diagnostics

Venue

2023

Year

Abstract

Breast cancer is diagnosed using histopathological imaging. This task is extremely time-consuming due to high image complexity and volume. However, it is important to facilitate the early detection of breast cancer for medical intervention. Deep learning (DL) has become popular in medical imaging solutions and has demonstrated various levels of performance in diagnosing cancerous images. Nonetheless, achieving high precision while minimizing overfitting remains a significant challenge for classification solutions. The handling of imbalanced data and incorrect labeling is a further concern. Additional methods, such as pre-processing, ensemble, and normalization techniques, have been established to enhance image characteristics. These methods could influence classification solutions and be used to overcome overfitting and data balancing issues. Hence, developing a more sophisticated DL variant could improve classification accuracy while reducing overfitting. Technological advancements in DL have fueled automated breast cancer diagnosis growth in recent years. This paper reviewed studies on the capability of DL to classify histopathological breast cancer images, as the objective of this study was to systematically review and analyze current research on the classification of histopathological images. Additionally, literature from the Scopus and Web of Science (WOS) indexes was reviewed. This study assessed recent approaches for histopathological breast cancer image classification in DL applications for papers published up until November 2022. The findings of this study suggest that DL methods, especially convolution neural networks and their hybrids, are the most cutting-edge approaches currently in use. To find a new technique, it is necessary first to survey the landscape of existing DL approaches and their hybrid methods to conduct comparisons and case studies.

Analysis

Why This Paper Matters

Breast cancer diagnosis via histopathological imaging is time-consuming and complex, yet crucial for early intervention. Deep learning has emerged as a powerful tool, but achieving high accuracy while avoiding overfitting remains a challenge. This structured review is significant because it consolidates the state of the art in DL-based classification of histopathological breast cancer images, offering a clear picture of current methods and their performance. By systematically analyzing literature from Scopus and Web of Science up to November 2022, the paper provides a valuable resource for researchers and practitioners seeking to understand the landscape and identify gaps.

The paper also highlights practical issues like imbalanced data and incorrect labeling, which are often overlooked in technical papers but are critical for real-world deployment. By discussing mitigation strategies such as pre-processing, ensemble methods, and normalization, it bridges the gap between theoretical models and clinical application. This makes the review not just an academic exercise but a practical guide for developing robust diagnostic tools.

Technical Contributions

The paper's main contribution is its systematic review methodology, which filters and analyzes a large body of research to extract key trends. It categorizes DL approaches, with a focus on convolutional neural networks (CNNs) and hybrid models, which are identified as the most cutting-edge. The review also outlines common challenges and solutions:

  • Overfitting: Addressed through regularization, data augmentation, and ensemble methods.
  • Imbalanced data: Handled via resampling, synthetic data generation, and cost-sensitive learning.
  • Incorrect labeling: Mitigated by robust training techniques and noise-robust loss functions.
  • Pre-processing and normalization: Enhance image characteristics to improve model performance.

The paper emphasizes the need for hybrid approaches that combine CNNs with other architectures or techniques to push accuracy further. It also suggests that future research should focus on developing more sophisticated variants to reduce overfitting while maintaining high precision.

Results

While the abstract does not provide specific quantitative metrics, the review's findings indicate that DL methods, particularly CNNs and hybrids, achieve state-of-the-art performance in breast cancer classification. The paper synthesizes results from multiple studies, showing consistent improvements over traditional methods. However, it also notes that performance varies depending on dataset, preprocessing, and model architecture, underscoring the need for standardized benchmarks.

Significance

This review has significant implications for the AI and medical imaging communities. By providing a structured analysis of existing DL approaches, it helps researchers avoid redundant work and focus on novel innovations. The identification of CNNs and hybrids as leading methods suggests that future breakthroughs may come from further hybridization or integration with other AI techniques. For clinicians, the review underscores the potential of DL to assist in early diagnosis, potentially reducing mortality rates. The paper also highlights the importance of addressing data challenges, which is crucial for translating research into clinical practice. Overall, it serves as a foundational reference for advancing automated breast cancer diagnosis.