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Large Language Models

Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey

Chen Ling(Emory University), Xujiang Zhao(NEC (United States)), Jiaying Lu(Emory University), Chengyuan Deng(Rutgers, The State University of New Jersey), Can Zheng(University of Pittsburgh), Junxiang Wang(NEC (United States)), Tanmoy Chowdhury(George Mason University), Yun Li(George Mason University), Hejie Cui(Emory University), Xuchao Zhang(Microsoft (United States)), Tianjiao Zhao(BlackRock (United States)), Amit Panalkar(BlackRock (United States)), Dhagash B. Mehta(BlackRock (United States)), Stefano Pasquali(BlackRock (United States)), Wei Dong Cheng(NEC (United States)), Haoyu Wang(NEC (United States)), Yanchi Liu(NEC (United States)), Zhengzhang Chen(NEC (United States)), Haifeng Chen(NEC (United States)), Chris White(NEC (United States)), Quanquan Gu(University of California, Los Angeles), Jian Pei(Duke University), Carl Yang(Emory University), Liang Zhao(Emory University)
September 3, 2025ACM Computing Surveys147 citations

147

Citations

0

Influential Citations

ACM Computing Surveys

Venue

2025

Year

Abstract

Large language models (LLMs) have significantly advanced the field of natural language processing (NLP), providing a highly useful, task-agnostic foundation for a wide range of applications. However, directly applying LLMs to solve sophisticated problems in specific domains meets many hurdles, caused by the heterogeneity of domain data, the sophistication of domain knowledge, the uniqueness of domain objectives, and the diversity of the constraints (e.g., various social norms, cultural conformity, religious beliefs, and ethical standards in the domain applications). Domain specification techniques are key to making large language models disruptive in many applications. Specifically, to solve these hurdles, there has been a notable increase in research and practices conducted in recent years on the domain specialization of LLMs. This emerging field of study, with its substantial potential for impact, necessitates a comprehensive and systematic review to summarize better and guide ongoing work in this area. In this article, we present a comprehensive survey on domain specification techniques for large language models, an emerging direction critical for large language model applications. First, we propose a systematic taxonomy that categorizes the LLM domain-specialization techniques based on the accessibility to LLMs and summarizes the framework for all the subcategories as well as their relations and differences to each other. Second, we present an extensive taxonomy of critical application domains that can benefit dramatically from specialized LLMs, discussing their practical significance and open challenges. Last, we offer our insights into the current research status and future trends in this area.

Analysis

Why This Paper Matters

Large language models (LLMs) have become a foundation for many NLP applications, but applying them directly to specialized domains often falls short due to heterogeneous data, complex domain knowledge, unique objectives, and diverse constraints such as social norms and ethical standards. This survey addresses the growing need to understand how to specialize LLMs for domains, a critical step for making them disruptive in real-world applications. By providing a comprehensive and systematic review, the paper helps consolidate a rapidly expanding body of research that has lacked a unified framework.

The authors argue that domain specialization is key to overcoming the hurdles of applying LLMs in specialized contexts. As LLMs are increasingly deployed in high-stakes domains like healthcare, finance, and law, understanding how to adapt them effectively is essential. This survey fills a gap by organizing existing techniques and application domains, offering a structured overview that can guide both researchers and practitioners. Given the 147 citations, the paper has already garnered attention, underscoring its relevance to the community.

Moreover, the survey's focus on accessibility to LLMs as a basis for taxonomy is particularly timely, as many organizations face choices between using proprietary APIs, open-source models, or training from scratch. By categorizing techniques along this dimension, the paper provides practical guidance for selecting appropriate specialization methods based on resource constraints and requirements.

Technical Contributions

  • Taxonomy of Domain-Specialization Techniques: The paper proposes a systematic taxonomy that categorizes techniques based on accessibility to LLMs. This includes categories such as training from scratch, continual pretraining, fine-tuning, and prompting, along with their subcategories and relationships.
  • Application Domain Taxonomy: It presents an extensive taxonomy of critical application domains that can benefit from specialized LLMs, discussing their practical significance and open challenges. This helps map techniques to domains and identify gaps.
  • Framework for Subcategories: For each subcategory, the paper summarizes the framework, relations, and differences, providing a clear overview of the landscape.
  • Insights and Future Trends: The authors offer insights into the current research status and future trends, highlighting open problems and potential directions for domain specialization.

Results

As a survey paper, there are no experimental results or quantitative metrics. Instead, the paper synthesizes existing literature and provides qualitative analysis. It organizes techniques and applications into taxonomies, which serve as a structured summary of the field. The paper discusses the practical significance of specialized LLMs in various domains and identifies open challenges, but does not report performance comparisons or benchmarks. The value lies in its comprehensive coverage and systematic organization rather than empirical findings.

Significance

The survey's significance lies in its potential to shape research and practice in LLM domain specialization. By providing a clear taxonomy and identifying open challenges, it helps researchers navigate the growing literature and identify promising directions. For practitioners, it offers a framework for choosing specialization techniques based on accessibility and domain requirements. The paper also highlights the importance of considering domain-specific constraints, such as ethical and cultural norms, which are often overlooked. As LLMs continue to permeate specialized domains, this survey will serve as a foundational reference for making LLMs disruptive in those areas. Its impact is likely to be felt in both academia and industry, guiding the development of more effective and responsible domain-specialized LLMs.